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This function was initially defined as a non-enzymatic role of SHMT2 by Miriam Waldens team [61, 62]

Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells

It also modulates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), which helps clear damaged proteins and prevent excessive breakdown of the extracellular matrix

As many as 80-90% of people following a vegan lifestyle may have a deficiency and the reason for this is that vitamin B12 is only found in animal food sources

Collagen fibers are thicker and coarser in the inner dermal layer than in the outer layer, with thinner and more tenuous collagen fibers (68)